Why the study?
The relationship between NAFLD and T2DM is bidirectional, with T2DM promoting the progression of NAFLD into NASH, creating a need to evaluate approaches to NASH in these patients.
Observational (n=59)
Open-label
p-value: p=0.003 and 0.03
Serum ferritin and NPAR are significantly elevated in T2DM patients with NASH compared to those with simple hepatic steatosis, suggesting their potential as non-invasive inflammatory biomarkers.
(1) Background: The relationship between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) is bidirectional: NAFLD increases the risk of T2DM, and T2DM promotes the progression of the disease into non-alcoholic steatohepatitis (NASH). (2) Material and methods: We performed a retrospective, open study that included 59 patients with NAFLD and T2DM who were distributed into two groups: 44 (74.57%) patients were diagnosed with hepatic steatosis (HS) and 15 (25.42%) patients were diagnosed with NASH. (3) Results: Among the non-specific inflammatory biomarkers, serum ferritin (SF) and the neutrophil-percentage-to-albumin ratio (NPAR) showed higher and statistically significant mean values (p = 0.003 respectively p = 0.03) in the group of patients with NASH and T2DM. Conclusions: Consequently, it is essential to identify alternative markers for the inflammatory process, particularly in individuals with diabetes, as it is a key characteristic of NASH. This need arises from the desire to avoid the risks associated with liver biopsy procedures (LBP) and to prevent the unpredictable and unfavorable progression of NAFLD in patients with T2DM.
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Stan et al. (2023) conducted an observational in NAFLD and T2DM (n=59). NASH vs. Hepatic steatosis (HS) was evaluated on Serum ferritin (SF) and neutrophil-percentage-to-albumin ratio (NPAR) (p=0.003 and 0.03).
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