Why the study?
The relationship between NAFLD and T2DM is bidirectional, with T2DM promoting the progression of NAFLD to NASH.
Are non-specific inflammatory biomarkers such as ferritin and neutrophil percentage-to-albumin ratio elevated in T2DM patients with NASH compared to those with simple hepatic steatosis?
Observational (n=59)
Open-label
Are non-specific inflammatory biomarkers such as ferritin and neutrophil percentage-to-albumin ratio elevated in T2DM patients with NASH compared to those with simple hepatic steatosis?
p-value: p=0.003 and 0.03
Ferritin and the neutrophil percentage-to-albumin ratio (NPAR) may serve as useful surrogate inflammatory markers to identify NASH in patients with T2DM and NAFLD.
Abstract: (1) Background: The relationship between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) is bidirectional: NAFLD increases the risk of T2DM, and T2DM promotes the progression of the disease to non-alcoholic steatohepatitis (NASH). (2) Material and methods: We performed a retrospective, open study that included 59 patients with NAFLD and T2DM who were distributed into two groups: 44 (74.57%) patients were diagnosed with HS and 15 (25.42%) patients were diagnosed with NASH. (3) Results: Among the non-specific inflammatory biomarkers statistically significant (p=0.003 respectively p=0.03) higher mean values were recorded in patients with NASH and T2DM in the case of ferritin and the neutrophil percentage-to-albumin ratio (NPAR). (4) Conclusions: Consequently, it is essential to identify alternative "surrogate" markers for the inflammatory process, particularly in individuals with diabetes, as it is a key characteristic of NASH. This need arises from the desire to avoid the risks associated with liver biopsy procedures and to prevent the unpredictable and unfavorable progression of NAFLD in patients with T2DM.
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Stan et al. (2023) conducted an observational in Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) (n=59). Non-alcoholic steatohepatitis (NASH) vs. Hepatic steatosis (HS) was evaluated on Non-specific inflammatory biomarkers (ferritin and neutrophil percentage-to-albumin ratio) (p=0.003 and 0.03).
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