Enlargement of Catheter Ablation Lesions in Infant Hearts With Cryothermal Versus Radiofrequency Energy
Key result
Cryothermal ablation lesions in immature myocardium enlarged to a similar extent as radiofrequency lesions, with no difference in growth rate in atria (P=0.44) or ventricles (P=0.57).
Why the study?
Does cryothermal ablation reduce the enlargement of ablation lesions over time compared to radiofrequency ablation in infant hearts?
Population
32 infant miniature swine undergoing catheter ablation
Comparison
Cryothermal ablation using 7F 4-mm electrode-tip… vs Radiofrequency ablation using 7F 4-mm…
Design
Preclinical, randomized factorial design
Follow-up
up to 12 months
Authors
Discussion
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Implication
Lesion growth is comparable for both modalities in immature hearts; leaves open translation to pediatric patients.
Study Design
Type
RCT (n=32)
Randomization
Factorial design
Structured PICO
Does cryothermal ablation reduce the enlargement of ablation lesions over time compared to radiofrequency ablation in infant hearts?
P
Population
32 infant miniature swine (weighing 8.8±1.2 kg, 63±13 days of age) undergoing catheter ablation (n=384 lesions in atria, ventricles, and AV grooves)
I
Intervention
Cryothermal ablation using 7F 4-mm electrode-tip catheters
C
Comparator
Radiofrequency ablation using 7F 4-mm electrode-tip catheters
O
Outcome
Rate of growth of ablation lesions (volume and depth) assessed morphometrically at acute, 1, 6, or 12 months post-ablationsurrogate
Main Result
p-value: p=0.44 (atria), 0.57 (ventricles), 0.69 (AV grooves)
Cryothermal ablation lesions in immature myocardium enlarge over time to a similar extent as radiofrequency ablation lesions, suggesting both modalities carry similar risks of late lesion enlargement in pediatric patients.
Cite This Study
Khairy et al. (2011) conducted an RCT in Ablation lesions in immature hearts (n=32). Cryothermal ablation vs. Radiofrequency ablation (average temperature 54.4±5.5°C) was evaluated on Rate of growth of ablation lesions (p=0.44 (atria), 0.57 (ventricles), 0.69 (AV grooves)). Cryothermal ablation lesions in immature myocardium enlarged to a similar extent as radiofrequency lesions, with no difference in growth rate in atria (P=0.44) or ventricles (P=0.57).