Key result
Rutin demonstrates beneficial effects on cardiac remodeling by improving cardiac structure and function across several cardiac disease models via multiple molecular and cellular pathways.
Why the study?
Rutin possesses potential cardioprotective effects in cardiac remodeling, but existing studies often focus on secondary manifestations rather than the underlying cellular and molecular mechanisms of disease progression.
Does rutin improve cardiac remodeling and function in cardiac disease models?
Does rutin improve cardiac remodeling and function in cardiac disease models?
Rutin demonstrates potential cardioprotective effects by modulating molecular and cellular pathways involved in cardiac remodeling, highlighting its potential as a future therapy for heart failure.
Should not yet change heart failure practice; leaves open translation of preclinical remodeling benefits to randomized trials.
Rutin has been demonstrated to possess potential cardioprotective effects in cardiac remodeling. Thus, the purpose of this review is to present gathered information on the roles of rutin in cardiac remodeling, which has gained attention as a therapeutic target in cardiac pathology, particularly heart failure. Such studies are focusing more on secondary manifestations and primary endpoints of cardiac dysfunction, rather than targeting cellular and molecular mechanisms that are responsible for cardiac disease progression. Recent scientific evidence has revealed the effects of rutin on molecular and cellular changes in cardiac remodeling pathogenesis. Conclusively, rutin shows beneficial effects on cardiac remodeling, evidenced by its effects on cardiac structure and function in several cardiac disease models via multiple pathways. Understanding its current roles in cardiac remodeling, helps in terms of further research on rutin be designed for its development as a potential therapy in cardiac remodeling, and then heart failure.
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Siti et al. (2019) conducted a review in Cardiac remodeling. Rutin was evaluated. Rutin demonstrates beneficial effects on cardiac remodeling by improving cardiac structure and function across several cardiac disease models via multiple molecular and cellular pathways.
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