What does this research mean for the field?

Angiotensin II promotes cardiac hypertrophy by activating STAT3 and STAT6 proteins, which bind to the angiotensinogen promoter to stimulate its transcription and drive an autocrine Angiotensin II loop. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 12, 1998Proceedings of the National Academy of SciencesOpen Access

Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: A cellular signal for hypertrophy in cardiac muscle

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Why the study?

Does Angiotensin II activate STAT proteins to promote angiotensinogen transcription in cardiac hypertrophy models?

Population

Cultured cardiomyocytes and hypertrophied hearts of genetically hypertensive rats

Comparison

Angiotensin II (AngII) treatment vs Untreated cardiomyocytes and normotensive WKY rats

Design

Preclinical

Authors

EMEduardo MascarenoRutgers, The State University of New Jersey MDManya DharState University of New York MSM.A.Q. SiddiquiAga Khan University

Discussion

Member takes

Implication

STAT activation by AngII may drive hypertrophy in animal models; extends mechanistic observations but remains hypothesis-generating for humans.

Structured PICO

Does Angiotensin II activate STAT proteins to promote angiotensinogen transcription in cardiac hypertrophy models?

Population

Cultured cardiomyocytes and hypertrophied hearts of genetically hypertensive rats (compared to aged-matched normotensive strain WKY)

Intervention

Angiotensin II (AngII) treatment

Comparator

Untreated cardiomyocytes and normotensive WKY rats

Outcome

Activation of STAT proteins (STAT3 and STAT6) and binding to the St-domain in the angiotensinogen promotersurrogate

Angiotensin II promotes cardiac hypertrophy by activating STAT3 and STAT6, which bind to the angiotensinogen promoter to increase its transcription.

Cite This Study

Mascareno et al. (1998) studied this question.

synapsesocial.com/papers/6a1d6fdb5b7fddc352054875 https://doi.org/10.1073/pnas.95.10.5590

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Implication

STAT activation by AngII may drive hypertrophy in animal models; extends mechanistic observations but remains hypothesis-generating for humans.