Population
Isolated papillary muscle and an innervated, isovolumetric heart in situ
Comparison
Alterations in end diastolic volume, fiber… vs Baseline states or varying levels of the…
Design
Preclinical
Authors
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May refine experimental contractility assessment; leaves open human translation and clinical validation.
The ratio of maximum rate of isometric tension development to integrated isometric tension (dp/dt/IIT) serves as a quantitative, length-independent index of myocardial contractility.
Siegel et al. (1963) studied this question.
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