Key result
Effective ablation sites are associated with greater local impedance drops, optimally around ~12 ohms.
Why the study?
A novel ablation catheter capable of local impedance monitoring was recently introduced, but the optimal local impedance drops for effective radiofrequency ablation during cavo-tricuspid isthmus ablation remained to be determined.
Does local impedance drop predict effective radiofrequency ablation during cavo-tricuspid isthmus ablation?
Population
50 consecutive patients undergoing CTI ablation using the IntellaNav MiFi OI catheter
Comparison
Evaluation of absolute and percentage local impedance drops during radiofrequency applications
Design
Retrospective observational study
Authors
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Local impedance drop ≥12 ohms may predict effective CTI lesions; hypothesis-generating pending prospective outcome trials.
Observational (n=50)
No
Does local impedance drop predict effective radiofrequency ablation during cavo-tricuspid isthmus ablation?
Absolute Event Rate: 15% vs 8%
p-value: p=<.0001
Local impedance drops of ≥12 ohms and ≥11.6% are useful biophysical markers for predicting effective lesion formation during CTI ablation.
Sasaki et al. (2020) conducted an observational in Cavo-tricuspid isthmus (CTI) dependent atrial flutter or atrial fibrillation (n=50). Local impedance (LI) monitoring vs. Ineffective RF ablation sites was evaluated on Absolute local impedance drop at effective vs ineffective RF ablation sites (p=<.0001). Effective radiofrequency ablation sites exhibited significantly greater absolute and percentage local impedance drops compared to ineffective sites, with optimal cutoffs of 12 ohms and 11.6%.
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