What does this research mean for the field?

While platelet nitric oxide synthase type 3 (NOS3) pathway dysfunction is evident in essential hypertension, the role of endothelial-derived nitric oxide remains controversial, as does whether these nitric oxide disturbances are a cause or consequence of elevated blood pressure. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 17, 2009Journal of Hypertension

Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension

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Population

Patients with essential hypertension

Design

Review

Authors

ΕGΕugenia GkaliagkousiVascular Medicine ΣΔΣτέλλα ΔούμαAristotle University of Thessaloniki CZChrysanthos ZamboulisAristotle University of Thessaloniki

Discussion

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Implication

Controversy on nitric oxide dysfunction in hypertension persists; leaves open causality and should not guide therapy.

Structured PICO

Population

Patients with essential hypertension

This review highlights the complex and controversial role of endothelial and platelet-derived nitric oxide dysfunction in the pathogenesis of essential hypertension.

Cite This Study

Gkaliagkousi et al. (2009) studied this question.

synapsesocial.com/papers/6a1d77c4750575be8d2f87ec https://doi.org/10.1097/hjh.0b013e328330e89a

Topics

Hypertension management

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Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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