What does this research mean for the field?

Increasing antioxidant availability may restore the bioactivity of endothelium-derived nitric oxide, which is typically impaired by oxidative stress in diseases such as atherosclerosis. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 18, 2000Cardiovascular ResearchOpen Access

Antioxidants and the bioactivity of endothelium-derived nitric oxide

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Design

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Authors

DTDouglas TomasianBoston University

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Implication

Antioxidant therapy should not yet change practice in atherosclerosis; leaves open whether restoring NO bioactivity improves outcomes.

Structured PICO

Intervention

Antioxidants

This review discusses the role of oxidative stress in impairing endothelium-derived nitric oxide bioactivity and the potential for antioxidants to restore NO-dependent responses in atherosclerosis.

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Douglas Tomasian (2000) studied this question.

synapsesocial.com/papers/6a1d77c4750575be8d2f87f5 https://doi.org/10.1016/s0008-6363(00)00103-6

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Antioxidants and the bioactivity of endothelium-derived nitric oxide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antioxidants and the bioactivity of endothelium-derived nitric oxide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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