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Gut immune homeostasis breakdown is central to the pathogenesis of both Crohn's disease (CD) and ulcerative colitis (UC). Apprehension of local imbalances in pro- and antiinflammatory signaling common to both led to the collective term 'inflammatory bowel disease' (IBD), a malady afflicting one and one-half million Americans.
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Dominick L. Auci (2016) studied this question.
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