Relationships between physical activity, healthy eating and cortical thickness in children and young adults

Prior neuroimaging studies have shown associations between healthy lifestyle factors and cortical thickness measurements; however, results on the direction of the association between cortical thickness, a measure of gray matter width, and healthy lifestyle factors have been inconsistent. While the majority of studies were performed in older adults within specific weight status categories, little has been reported in younger populations with a range of adiposity, including groups with healthy-weight, overweight and obesity. Here we investigated relationships between indices of physical activity (PA) and healthy eating with cortical thickness in children and young adults and examined whether these relationships differed by weight status and age groups. Study participants included 119 young adults and 159 children. We hypothesized that greater levels of PA and/or healthy eating index (HEI) composite scores would be positively associated with cortical thickness across age groups, and that this association would differ in overweight or obese groups versus normal weight groups. Overall PA (minutes/day) was assessed using 24-hour PA recalls. HEI was calculated to assess diet quality. A structural MRI was performed, and FreeSurfer 6.0 was used to assess cortical thickness in 68 regions of interest (ROI). Mixed effects modeling was performed to investigate associations of PA or HEI with cortical thickness. FDR corrections were applied for multiple ROIs. PA was positively associated with cortical thickness in the caudal middle frontal cortex (FDR adjusted p = 0.042) and cuneus cortex (FDR adjusted p = 0.017), after controlling for sex, age group and weight status. When stratified by age, in young adults, higher time spent in PA was associated with greater cortical thickness in the frontal, temporal, parietal and occipital cortex, after adjusting for sex and weight group (FDR adjusted ps < 0.05). No significant associations between PA and cortical thickness were observed in children. No significant associations between HEI and cortical thickness were observed. These results indicate that higher time spent in PA is associated with greater cortical thickness, a relationship that appears to be stronger during young adulthood and may be related to more favorable brain health outcomes.