Key result
Lercanidipine effectively reduces blood pressure, provides organ protection, and causes fewer peripheral edema compared to other calcium antagonists in patients with hypertension.
Why the study?
Does lercanidipine reduce blood pressure and provide organ protection in patients with hypertension?
Does lercanidipine reduce blood pressure and provide organ protection in patients with hypertension?
Lercanidipine is an effective antihypertensive agent with organ-protective properties and a favorable safety profile regarding peripheral edema.
May support lercanidipine preference to limit edema in hypertension; leaves open prospective outcome trials.
The article presents the results of studies on the effectiveness and safety of a III generation calcium antagonist lercanidipine in the treatment of hypertension. Lercanidipine treatment leads to a marked significant reduction in systolic and diastolic blood pressure without producing a significant effect on heart rate. The drug has organ-protective effect, reduces left ventricular hypertrophy, improves kidney function and has antiproteinuric action. Lercanidipine is well tolerated, less likely to cause peripheral edema compared with other calcium antagonists.
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Барышникова et al. (2014) conducted a review in Hypertension. Lercanidipine vs. Other calcium antagonists and antihypertensive drugs was evaluated. Lercanidipine effectively reduces blood pressure, provides organ protection, and causes fewer peripheral edema compared to other calcium antagonists in patients with hypertension.
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