Modulation of slow inactivation in human cardiac Kv1.5 channels by extra‐ and intracellular permeant cations
Population
Human heart K+ channel hKv1.5
Comparison
Modulation by extra- and intracellular permeant… vs Different cation species and concentrations
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Cation modulation of Kv1.5 inactivation is hypothesis-generating; leaves open ion-binding sites as therapeutic targets in atrial arrhythmias pending human validation.
Structured PICO
P
Population
Human heart K+ channel hKv1.5
I
Intervention
Modulation by extra- and intracellular permeant cations (Rb+, Cs+, K+, Na+) and mutation of residues (R487)
C
Comparator
Different cation species and concentrations
O
Outcome
Properties and regulation of slow inactivation (degree of inactivation, voltage dependence, inactivation time constants)surrogate
Intracellular and extracellular cations modulate slow inactivation in human cardiac Kv1.5 channels, suggesting the presence of ion binding sites capable of regulating inactivation on both sides of the pore selectivity filter.
Cite This Study
Fedida et al. (1999) studied this question.