Regulation of N- and C-type inactivation of Kv1.4 by pHoand K+: evidence for transmembrane communication

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Structured PICO

Population

Kv1.4 potassium channels (including NH2-terminal deletion mutant fKv1.4DeltaN and point mutations V561A, K532Y)

Intervention

Alterations in extracellular/intracellular K+ concentration (e.g., 98 mM [K+]o) and extracellular pH (acidosis)

Comparator

Standard conditions or wild-type channels

Outcome

N- and C-type inactivation kineticssurrogate

Mutations, potassium concentrations, and pH modulate Kv1.4 channel inactivation through membrane-spanning mechanisms involving the S6 segment.

No takes yet. Share an insight, caveat, or question.

Should not yet inform arrhythmia management in acidosis; hypothesis-generating for pH effects on Kv1.4 inactivation.

Li et al. (2003) studied this question.

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