The Dysgammaglobulinemic Syndrome

Article1 February 1959THE DYSGAMMAGLOBULINEMIC SYNDROMEWILLIAM J. HAMMACK, M.D., F. ELNA BOLDING, B.S., WALTER B. FROMMEYER JR., M.D., F.A.C.P.WILLIAM J. HAMMACK, M.D.Search for more papers by this author, F. ELNA BOLDING, B.S.Search for more papers by this author, WALTER B. FROMMEYER JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-2-288 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPlasma protein electrophoretic patterns revealing discrete and homogeneous globulin peaks have been interpreted to indicate either multiple myeloma, cryoglobulinemia or macroglobulinemia. The increased serum globulin found in cirrhosis, hyperglobulinemic purpura and hepatitis exhibits on paper electrophoresis diffuse and rounded peaks that are distinct from the discrete and homogeneous serum electrophoretic peaks found in the patients forming the basis of this report. Four male patients with discrete serum gamma globulin electrophoretic peaks have been observed for from two to three and one-half years without evidence of specific disease other than an inordinate susceptibility to infections. Although multiple myeloma may subsequently develop...Bibliography1. Spinco Model R Manual OIR-1. Belmont, California, Spinco Division Beckman Instruments, Inc., n.d. Google Scholar2. JacobsonMilner BMLR: Detection of urinary Bence Jones protein, Am. J. Clin. Path. 14: 138, 1944. CrossrefGoogle Scholar3. WolfsonCohnCalvaryIchiba WQCEF: Studies in serum proteins; rapid procedure for estimation of total protein, true albumin, total globulin, alpha globulin, beta globulin and gamma globulin in 1.0 ml. of serum, Am. J. Clin. Path. 18: 723, 1948. CrossrefMedlineGoogle Scholar4. KorngoldLipari LR: Multiple myeloma proteins. I. Immunological studies, Cancer 9: 183, 1956. CrossrefMedlineGoogle Scholar5. PetermannHamiltonKorngold MLMGL: Multiple myeloma proteins. II. Ultracentrifugal and electrophoretic analysis of a paucidisperse myeloma globulin, Cancer 9: 193, 1956. CrossrefMedlineGoogle Scholar6. KorngoldVanLeeuwen LG: Macroglobulinemia. I. The antigenic relationship of pathological macroglobulins to normal gamma globulins, J. Exper. Med. 106: 467, 1957. CrossrefMedlineGoogle Scholar7. PillemerBlumLepowWurzTodd LLIHLEW: The properdin system and immunity. III. The zymosan assay of properdin, J. Exper. Med. 103: 1, 1956. CrossrefMedlineGoogle Scholar8. GoodZak RASJ: Disturbances in gamma globulin synthesis as "experiments of nature," Pediatrics 18: 109, 1956. MedlineGoogle Scholar9. Lawson HA: Congenital afibrinogenemia, New England J. Med. 248: 552, 1953. CrossrefMedlineGoogle Scholar10. RiegelThomas CD: Absence of beta globulin fraction in the serum protein of a patient with unexplained anemia, New England J. Med. 255: 434, 1956. CrossrefMedlineGoogle Scholar11. WolstenholmeMillar GEEC, Editors: Ciba Foundation symposium on paper electrophoresis, 1956, Little, Brown and Company, Boston. CrossrefGoogle Scholar12. OwenRider JAWD: Electrophoretic analysis of serum and urinary proteins in the diagnosis of myelomatosis, J. Clin. Path. 10: 373, 1957. CrossrefMedlineGoogle Scholar13. MackayEriksenMotulskyVolwiler IRNAGW: Cryo- and macroglobulinemia, Am. J. Med. 20: 564, 1956. CrossrefMedlineGoogle Scholar14. BarnettCurtainHayesHoldenPyeO'Donnell AJCCRAHFJI: Cryoglobulinemia, Australasian Ann. Med. 5: 177, 1956. CrossrefMedlineGoogle Scholar15. KorstKratochvil DRCH: "Cryofibrinogen" in a case of lung neoplasm associated with thrombophlebitis migrans, Blood 10: 945, 1955. CrossrefMedlineGoogle Scholar16. MartinMathieson WJDR: Pyroglobulinemia (heat-coagulable globulin in the blood), Proc. Staff Meet., Mayo Clin. 28: 549, 1953. Google Scholar17. HuismanVan Der WalGroenVan Der Sar THBAA: Investigations on a heat-coagulable globulin in the blood of a patient with multiple myeloma, Clinica Chimica Acta 1: 525, 1956. CrossrefMedlineGoogle Scholar18. BloomShulmanWitebsky MLSE: Anticomplementary activity of multiple myeloma, Clin. Res. 6: 206, 1958. Google Scholar19. Smith EW: Non-myelomatous paraproteinemia, Clin. Res. Proc. 5: 158, 1957. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Birmingham, Alabama*Received for publication July 7, 1958.From the Department of Medicine, University of Alabama College of Medicine, and Veterans Administration Hospital, Birmingham, Alabama.Presented in part at the Southeastern Regional Meeting of The American College of Physicians, St. Simons Island, Georgia, October 4-5, 1957.†These studies were supported in part by Research Grant CY-3013 from the National Cancer Institute of the National Institutes of Health, Public Health Service.Requests for reprints should be addressed to Walter B. Frommeyer, Jr., M.D., Professor and Chairman, Department of Medicine, Medical College of Alabama, Birmingham, Alabama. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Benign Monoclonal Gammapathies: A Study of Monoclonal AntibodiesAN AUTOPSY CASE OF SO-CALLED DIFFUSE MYELOMA WITH PYROGLOBULINEMIAParaproteinämische HämoblastosenLeukemic form of immunocytic dyscrasia (plasma cell leukemia)Studies of Monoclonal Immunoglobulins (M-Components) in Various KindredsRALPH C. WILLIAMS JR., M.D., JEFFREY L. ERICKSON, B.A., HERBERT F. POLESKY, M.D., WILLIAM R. SWAIM, M.D.Die paraproteinämischen HämoblastosenDysimmunoglobulinemia in the absence of clinical features of multiple myeloma and macroglobulinemiaThe Treatment of Plasma Cell MyelomaCoexistent chronic myelocytic leukemia, monoclonal gammopathy and multiple chromosomal abnormalitiesThe Gamma GlobulinsClinical and immunologic features of dysgammaglobulinemia type I“Benign” monoclonal gammopathy: A potentially malignant condition?REFERENCESFrequency of Pathological Proteins (M-components) in 6,995 Sera from an Adult PopulationTHE USE OF GEL ELECTROPHORESIS IN THE DIAGNOSIS OF THE PARAPROTEINEMIAS*The Occurrence of Benign, Essential Monoclonal (M Type), Non-macromolecular Hyperglobulinemia and its Differential DiagnosisFrequency of “Abnormal” Serum Globulins (M-Components) in the AgedDIAGNOSIS OF MULTIPLE MYELOMA AND MACROGLOBULINEMIA BY THE OUCHTERLONY GEL DIFFUSION TECHNIQUE*INCIDENCE AND SIGNIFICANCE OF SEROPOSITIVE TESTS FOR RHEUMATOID FACTOR IN NONRHEUMATOID DISEASES*HARRY BARTFELD, M.D.Plasma-Cell Myeloma 1 February 1959Volume 50, Issue 2Page: 288-299KeywordsGlobulinsHospital medicineMultiple myelomaMyelomaPaper electrophoresisPlasma proteinsPneumoniaPrevention, policy, and public healthProteinsResearch grants ePublished: 1 December 2008 Issue Published: 1 February 1959 PDF downloadLoading ...