Multiple Myeloma: Diagnosis and Management in a Series of 57 Cases

Article1 June 1957MULTIPLE MYELOMA: DIAGNOSIS AND MANAGEMENT IN A SERIES OF 57 CASESJOHN J. KENNY, M.D., WILLIAM C. MOLONEY, M.D., F.A.C.P.JOHN J. KENNY, M.D.Search for more papers by this author, WILLIAM C. MOLONEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-6-1079 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMultiple myeloma, once considered an extremely rare disease, has been diagnosed with increasing frequency during the last decade. Whether this has been due to an actual increased incidence or to improved clinical and laboratory recognition is not known. Usually the diagnosis of multiple myeloma is not difficult, but the disease may be at times an obscure and insidious one. Although inevitably fatal, in some cases multiple myeloma may pursue a prolonged and chronic course, and in even the more malignant forms of the disease, chemotherapy and other measures may afford some relief. During the last nine years 57 cases of...Bibliography1. DavisonBalser CBA: Myeloma and its neural complications, Arch. Surg. 35: 913, 1937. CrossrefGoogle Scholar2. KurnickYohalem NBSB: Peripheral neuritis complicating multiple myeloma, Arch. Neurol. and Psychiat. 59: 378, 1954. CrossrefGoogle Scholar3. EstesMillikan HRCH: Polyneuritis and radiculitis associated with multiple myeloma: report of case, Proc. Staff Meet., Mayo Clin. 29: 453, 1954. MedlineGoogle Scholar4. LernerWatson ABCJ: Studies of cryoglobulins. I. Unusual purpura associated with the presence of a high concentration of cryoglobulin (cold precipitable serum globulin), Am. J. M. Sc. 214: 410, 1947. CrossrefMedlineGoogle Scholar5. AdamsAllingLawrence WSELJS: Multiple myeloma: its clinical and laboratory diagnosis with emphasis on electrophoretic abnormalities, Am. J. Med. 6: 141, 1949. CrossrefMedlineGoogle Scholar6. FowlerGordon WMJD: Multiple myeloma, Am. Pract. and Digest Treat. 1: 449, 1950. Google Scholar7. SnapperTurnerMoscovitz ILHL: Multiple myeloma, 1st Ed., 1953, Grune and Stratton, New York. Google Scholar8. Batts W: Multiple myeloma: review of forty cases, Arch. Surg. 39: 807, 1939. CrossrefGoogle Scholar9. BayrdHeck EDFJ: Multiple myeloma: a review of eighty-three proven cases, J. A. M. A. 133: 147, 1947. CrossrefMedlineGoogle Scholar10. Limarzi LR: Multiple myeloma: diagnostic and therapeutic aspects: a study based on 90 proven cases, J. Omaha Mid-West Clin. Soc. 13: 50, 1952. Google Scholar11. ErfHerbut LAPA: Comparative cytology of Wright's stained smears and histologic sections in multiple myeloma, Am. J. Clin. Path. 16: 1, 1946. CrossrefMedlineGoogle Scholar12. Wintrobe MM: Clinical hematology, 3d Ed., 1951, Lea and Febiger, Philadelphia. Google Scholar13. BiezerHallGriffin LHBEHZ: The diagnosis of multiple myeloma by sternal aspiration, Am. J. M. Sc. 203: 829, 1942. CrossrefGoogle Scholar14. Bayrd ED: The bone marrow of sternal aspiration in multiple myeloma, Blood 3: 987, 1948. CrossrefMedlineGoogle Scholar15. Putnam FW: Abnormal human serum globulins, Science 122: 275, 1955. CrossrefMedlineGoogle Scholar16. Marks J: Antibody formation in myelomatosis, J. Clin. Path. 6: 62, 1953. CrossrefMedlineGoogle Scholar17. LawsonStuartPaullPhillipsPhillips HACAAMAMRW: Observations on the antibody content of the blood in patients with multiple myeloma, New England J. Med. 252: 13, 1955. CrossrefMedlineGoogle Scholar18. GutmanMooreGutmanMcClellandKabot ABDHEBVEA: Fractionation of serum proteins in hyperproteinemia with special reference to multiple myeloma, J. Clin. Investigation 20: 765, 1941. CrossrefMedlineGoogle Scholar19. LewisBortzBattle LADWJD: Electrophoretic and ultracentrifugal analysis of serum proteins, multiple myeloma, Cleveland Clin. Quart. 18: 119, 1951. CrossrefGoogle Scholar20. RundlesCooperWillett RWFRRW: Multiple myeloma. IV. Abnormal serum component and Bence Jones protein, J. Clin. Investigation 30: 1125, 1951. CrossrefMedlineGoogle Scholar21. GeschikterCopeland CFMM: Multiple myeloma, Arch. Surg. 16: 807, 1928. CrossrefGoogle Scholar22. Coley WB: Multiple myeloma, Ann. Surg. 93: 77, 1931. CrossrefMedlineGoogle Scholar23. Atkinson FR: Multiple myelomata, M. Press 195: 312, 1937. Google Scholar24. PutnamMiyake FWA: On the nonidentity of Bence Jones protein, Science 120: 848, 1954. CrossrefMedlineGoogle Scholar25. OssermanLawlor EFDP: Abnormal serum and urine protein in thirty-five cases of multiple myeloma, as studied by filter paper electrophoresis, Am. J. Med. 18: 462, 1955. CrossrefMedlineGoogle Scholar26. Bell ET: Renal lesions associated with multiple myeloma, Am. J. Path. 9: 393, 1933. MedlineGoogle Scholar27. Sikl H: A case of diffuse plasmacytosis with deposition of protein crystals in the kidneys, J. Path. and Bact. 61: 149, 1949. CrossrefMedlineGoogle Scholar28. Trubowitz S: The sternal marrow aspiration of amyloid in multiple myeloma, Blood 5: 581, 1950. CrossrefMedlineGoogle Scholar29. Goltz RW: Systematized amyloidosis, Medicine 31: 381, 1952. CrossrefMedlineGoogle Scholar30. ChristophersonMiller WMAJ: A reëvaluation of solitary plasma cell myeloma of the bone, Cancer 3: 240, 1950. CrossrefGoogle Scholar31. BayrdHall EDBE: Unusual remission after radiophosphorus therapy in a case of acute plasma cell leukemia, Blood 3: 1019, 1948. CrossrefMedlineGoogle Scholar32. LawrenceWasserman JHLR: Multiple myeloma: a study of 24 patients treated with radioactive isotopes (P32 and SR69), Ann. Int. Med. 33: 41, 1950. LinkGoogle Scholar33. Bayrd ED: Sustained remission in multiple myeloma (Letter to the Editor), Blood 10: 662, 1955. Google Scholar34. GarlandKennedy LHBR: Roentgen treatment of multiple myeloma, Radiology 50: 297, 1948. CrossrefMedlineGoogle Scholar35. KrissBiermanThomasNewell JPHRSFRR: Treatment of multiple myeloma with radioactive iodine and radioactive iodinated serum albumin, Radiology 65: 241, 1955. CrossrefMedlineGoogle Scholar36. RundlesReeves RWRJ: Multiple myeloma. II. Variability of roentgen appearance and effect of urethane therapy on skeletal disease, Am. J. Roentgenol. 64: 799, 1950. Google Scholar37. RundlesDillonDillon RWMLES: Multiple myeloma. III. Effect of urethane therapy on plasma cell growth, abnormal serum protein components and Bence Jones proteinuria, J. Clin. Investigation 29: 1243, 1950. CrossrefMedlineGoogle Scholar38. HarringtonMoloney WJWC: The treatment of multiple myeloma with urethane, Cancer 3: 253, 1950. CrossrefGoogle Scholar39. LuttgensBayrd WFED: Treatment of multiple myeloma with urethane: experience with sixty-six cases over a two-and-a-half year period, J. A. M. A. 147: 824, 1951. CrossrefMedlineGoogle Scholar40. OhlerHoughtonMoloney RLJDWC: Urethane toxicity, report of a case of hepatic necrosis apparently due to urethane, New England J. Med. 243: 984, 1950. CrossrefMedlineGoogle Scholar41. LichtensteinJaffe LHL: Multiple myeloma: a survey based on thirty-five cases, eighteen of which came to autopsy, Arch. Path. 44: 207, 1947. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication June 8, 1956.From the Hematology Laboratory, I and III Medical Services (Tufts), Boston City Hospital.Assisted by a grant from the American Cancer Society, Massachusetts Division.†Charlton Research Fellow in Hematology (Tufts).Requests for reprints should be addressed to William C. Moloney, M.D., The Boston City Hospital, 818 Harrison Avenue, Boston 18, Massachusetts. 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WOLLHEIM, M.D.Ultrastructure of the kidney in a patient with multiple myelomaREFERENCESMyelomatosisActive `juvenile' cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapyDie Krankheitsdauer und �berlebenszeit beim multiplen MyelomParaproteinurien mit negativem Ausfall des Albustix-TestesStudies of the anemia of multiple myelomaWaldenström's macroglobulinemiaMyeloma and Pernicious AnaemiaMyelomatosis with Extensive Pulmonary InvolvementA CASE OF MULTIPLE MYELOMAChemotherapy of multiple myelomatosisMultiple myelomaMultiple myeloma manifested as a problem in the diagnosis of pulmonary diseaseMultiple MyelomaHypogammaglobulinaemia in MyelomaRENAL PATTERNS IN MYELOMA*L. M. SANCHEZ, M.D., C. A. DOMZ, M.D., F.A.C.P.Plasma-Cell Myeloma 1 June 1957Volume 46, Issue 6Page: 1079-1091KeywordsAdrenocorticotropic hormoneAnemiaChemotherapyClinical laboratoriesHematology and oncologyMedical servicesMultiple myelomaProteinsProteinuriaResearch laboratories ePublished: 1 December 2008 Issue Published: 1 June 1957 PDF downloadLoading ...