What does this research mean for the field?

Natural nonsense suppressor tRNAs misread termination codons through unconventional base pairings and specific nucleotide contexts, providing a regulatory mechanism of gene expression utilized by viruses and potentially eukaryotic hosts. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2001Nucleic Acids ResearchOpen Access

Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs

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Population

Eukaryotes and positive-sense ssRNA viruses

Design

Review

Authors

HBH. BeierUniversitätsklinikum Aachen

Discussion

Member takes

Implication

Natural tRNA readthrough may regulate viral gene expression; leaves open therapeutic targeting in nonsense mutation diseases.

Structured PICO

Population

Eukaryotes and positive-sense ssRNA viruses

Intervention

Natural nonsense suppressor tRNAs

Outcome

Translational stop codon readthrough

Translational stop codon readthrough by natural nonsense suppressor tRNAs provides a regulatory mechanism of gene expression utilized by viruses and potentially eukaryotic hosts.

Cite This Study

H. Beier (2001) studied this question.

synapsesocial.com/papers/6a1d8bb6266863fda62f727f https://doi.org/10.1093/nar/29.23.4767

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Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider