What does this research mean for the field?

During the early stages of pressure-overload-induced cardiac hypertrophy, alpha-skeletal actin and beta-myosin heavy chain mRNAs accumulate nonsynchronously and in distinct spatial patterns, indicating they are induced by different regulatory mechanisms. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1989Circulation ResearchOpen Access

Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.

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Population

25-day-old rats

Comparison

Thoracic aortic stenosis (pressure overload) vs Normal and sham-operated animals

Design

Preclinical

Follow-up

4 hours to 3 days

Authors

SSStefano SchiaffinoGeneral Cardiology JSJane‐Lise SamuelUniversité Paris Cité DSDavid SassoonInserm

Discussion

Member takes

Implication

Early LV mRNA discordance suggests distinct hypertrophic regulators; hypothesis-generating, no clinical translation yet.

Structured PICO

Population

25-day-old rats

Intervention

Thoracic aortic stenosis (pressure overload)

Comparator

Normal and sham-operated animals

Outcome

Regional distribution and accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAssurrogate

The nonsynchronous spatial and temporal accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs suggests different regulatory mechanisms are involved in their induction during early pressure overload-induced cardiac hypertrophy.

Cite This Study

Schiaffino et al. (1989) studied this question.

synapsesocial.com/papers/6a1d8ddc33e2df9c962fb33d https://doi.org/10.1161/01.res.64.5.937

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Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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