Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma

Janet R. Daling; Kathleen E. Malone; David R. Doody; Lisa Johnson; Julie R. Gralow; Peggy L. Porter

doi:10.1002/1097-0142(20010815)92:4<720::aid-cncr1375>3.0.co;2-t

January 1, 2001Cancer

Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma

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Key Points

To evaluate the relationship between body mass index, tumor proliferation characteristics, and mortality among young women diagnosed with invasive ductal breast carcinoma.
Followed a population-based cohort of 1,177 women younger than 45 years diagnosed with invasive ductal breast carcinoma between 1983 and 1992.
Evaluated tumor tissue and histologic specimens using pathologic review, immunohistochemistry assays, and bivariate flow cytometric analysis to measure proliferation and receptor status.
Women in the highest BMI quartile had 2.5 times higher 5-year mortality risk than those in the lowest quartile (95% CI, 1.6–3.9), remaining an independent predictor in multivariate analysis (HR, 1.7; 95% CI, 1.0–2.9; P < 0.05).
High BMI was significantly associated with estrogen receptor negativity (OR, 1.5; 95% CI, 1.0–2.2), high histologic grade (OR, 1.7; 95% CI, 1.0–2.9), and elevated mitotic cell count (OR, 2.0; 95% CI, 1.2–3.1).
Tumors in the highest BMI quartile exhibited elevated S-phase fractions (OR, 1.9; 95% CI, 1.2–3.1) and greater tumor size (2 to <5 cm: OR, 2.3; 95% CI, 1.5–3.1; ≥5 cm: OR, 2.7; 95% CI, 1.5–4.8).

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Implication

Cohort study reveals higher mortality and aggressive tumor markers in young women with elevated body mass index, indicating obesity drives faster-growing breast carcinoma.

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Daling et al. (2001) studied this question.

synapsesocial.com/papers/6a1d8e54ba65f5ee325e940f https://doi.org/10.1002/1097-0142(20010815)92:4<720::aid-cncr1375>3.0.co;2-t

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Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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