Key result
First-time TIA linked to ~414% higher ischemic stroke risk versus the background population.
Why the study?
The short-term incidence of ischemic stroke after TIA is high, but data on the long-term incidence are not well known to guide preventive strategies.
Does a first-time TIA increase the long-term risk of ischemic stroke and mortality compared to the general population and patients with first-time ischemic stroke?
Population
21 500 TIA patients, 86 000 background controls, and 21 500 stroke patients
Comparison
First-time TIA vs matched background population vs first-time ischemic stroke
Design
Nationwide matched registry-based cohort study
Follow-up
5 years
Authors
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May support extended post-TIA surveillance; leaves open whether intensified long-term interventions reduce observed stroke risk.
Cohort (n=129,000)
Yes
Does a first-time TIA increase the long-term risk of ischemic stroke and mortality compared to the general population and patients with first-time ischemic stroke?
Effect estimate: HR 5.14 (95% CI 4.65-5.69)
Absolute Event Rate: 6.1% vs 1.5%
p-value: p=<0.01
Patients with a first-time TIA have a 5-fold higher 5-year risk of ischemic stroke compared to the general population, highlighting the need for long-term preventive strategies.
Vinding et al. (2023) conducted a cohort in Transient Ischemic Attack (n=129,000). First-time TIA vs. Background population was evaluated on Incidence of ischemic stroke (HR 5.14, 95% CI 4.65-5.69, p=<0.01). First-time TIA was associated with a 5-year ischemic stroke incidence of 6.1%, significantly higher than the background population (1.5%; HR 5.14, 95% CI 4.65-5.69, P<0.01).
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