Key result
A historical review of antiarrhythmic drugs highlights their evolution since the 18th century and identifies combination therapy with radiofrequency ablation as a promising future treatment strategy.
Why the study?
Heart rhythm disorders represent one of the most urgent problems in cardiology, prompting an examination of the history and clinical use of antiarrhythmic drugs from past years to the present.
This historical review highlights the evolution of antiarrhythmic drug therapy and suggests that combining pharmacotherapy with radiofrequency ablation is a promising future strategy.
Answers are grounded in this paper and cite their sources.
Offers historical context without immediate practice change; leaves open efficacy of combined antiarrhythmic-ablation strategies for prospective trials.
Heart rhythm disorders are one of the most urgent problems in cardiology. The first reports on the possibility of using drugs in the treatment of cardiac arrhythmias began to appear in the scientific literature from the middle of the 18th century. This pharmacotherapeutic direction has been developed since the second half of the 20th century, when new antiarrhythmic drugs began to be used in clinical practice. The introduction of new drugs and modern methods of treating arrhythmias into clinical practice has significantly improved the prognosis and quality of life of patients. Combination antiarrhythmic therapy, including antiarrhythmic drugs and radiofrequency ablation, seems to be the most promising and successful tactic for treating patients in the future. A historical review of the literature on the clinical use of antiarrhythmic drugs both in past years and at present is presented in the article.
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Дощицин et al. (2022) conducted a review in Cardiac arrhythmias. Antiarrhythmic drugs was evaluated. A historical review of antiarrhythmic drugs highlights their evolution since the 18th century and identifies combination therapy with radiofrequency ablation as a promising future treatment strategy.
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