Key result
Angiotensin II type 1a receptor deficiency or pharmacological blockade significantly impaired ischemia-induced angiogenesis and blood flow recovery in a mouse model of hindlimb ischemia.
p-value: p=<0.05
May warrant caution with AT1a blockade in ischemia; leaves open translation to human PAD.
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Sasaki et al. (2002) studied Hindlimb ischemia. AT1a receptor deficiency or TCV-116 (AT1 receptor blocker) vs. Wild-type mice was evaluated on Ischemic/normal hindlimb blood flow ratio (p=<0.05). Angiotensin II type 1a receptor deficiency or pharmacological blockade significantly impaired ischemia-induced angiogenesis and blood flow recovery in a mouse model of hindlimb ischemia.
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