Key result
Serum levels of TNF and IL-6 were not significantly elevated in hypertensive patients with left ventricular hypertrophy compared to those with normal left ventricular mass (p = NS).
Why the study?
Are serum levels of TNF and IL-6 associated with elevated left ventricular mass in hypertensive patients?
Observational (n=35)
Are serum levels of TNF and IL-6 associated with elevated left ventricular mass in hypertensive patients?
p-value: p=NS
Serum levels of TNF and IL-6 are not significantly associated with elevated left ventricular mass in hypertensive patients receiving medical therapy.
The objective of this prospective study was to examine the association between serum levels of TNF (tumor-necrosis factor) and IL-6 (interleukin-6) and left ventricular mass in hypertensive patients. Hypertensive patients currently receiving medical therapy were eligible. All subjects underwent echocardiography with measurements of left ventricular (LV) mass and ejection fraction (EF) and had serum levels of TNF and IL-6 measured by ELISA immunoassay. 35 subjects (20F, 15M; mean age 56.4 +/- 10.5 yrs) were studied. 19 patients (54%) had elevated LV mass. Of these patients, 6 (32%) had detectable serum TNF levels and 1 (7%) had detectable IL-6 levels, (p = NS). Hypertensive patients with elevated LV mass do not consistently exhibit elevated cytokine levels when compared to those with normal LV mass.
No takes yet. Share an insight, caveat, or question.
Leibowitz et al. (2005) conducted an observational in Hypertension (n=35). Serum levels of TNF and IL-6 vs. Normal left ventricular mass was evaluated on Association between serum levels of TNF and IL-6 and left ventricular mass (p=NS). Serum levels of TNF and IL-6 were not significantly elevated in hypertensive patients with left ventricular hypertrophy compared to those with normal left ventricular mass (p = NS).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: