Correlation of Tumor Necrosis Factor with Left Ventricular Hypertrophy and Prehypertension in Non Diabetes Male Abdominal Obesity

Introduction : Left Ventricular Hypertrophy (LVH) as an independent predictor of mortality may develop in non diabetes obese.There's a role of inflammation because adipose tissue release the proinflammatory cytokines such as TNF α.It is important to prove this inflammatory state and its impact to the healthy obese for preventing cardiovascular events in the future.Purpose of this study is to investigate correlation of TNF α level with LVH and Prehypertension in non diabetes abdominal obesity.Methods : Eighty-two male abdominal obesity and non abdominal obesity subjects with no history of diabetes were recruited in this cross-sectional study.Tumor Necrosis Factor Alpha level were measured with radioimmunoassay, blood pressure measurement was taken 2 times.Left Ventricular Mass Index(LVMI) were evaluated by M-Mode and two dimension echocardiogram and value above 115 g/m2 are indicative of LVH.Result : TNFa alpha level is higher in abdominal obesity group as compare to non abdominal obesity (0,7133+0,2072 pg/ml vs 2,395+1,5371 pg/ml, p<0,001).Most of obese subjects developed prehypertension.Subjects with prehypertension showed higher plasma TNF alpha level as compare to subject with normal blood pressure (2,83+1,649 pg/ml vs 1,38 + 0,3245 pg/ml, p<0,001).We also found the LVH in 30 (60%) of abdominal obesity subjects.Obese subject had larger LVMI than non obese (138,427+47,461 g/m2 vs 90,188+16,06 g/m2, p<0,001), and correlates positively to plasma TNF alpha level (r=0,727, p,<0,001).Conclusion : High level of plasma TNF alpha is associated with left ventricular hypertrophy and prehypertension in non diabetes male abdominal obesity.