Key result
Voltage-gated potassium channel dysfunction in dorsal root ganglia mediates the exaggerated exercise pressor reflex and muscle afferent sensitization in rats with chronic heart failure.
Voltage-gated potassium channel dysfunction in dorsal root ganglia mediates the exaggerated exercise pressor reflex in chronic heart failure, highlighting a potential therapeutic target to improve exercise intolerance.
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May support KV channel modulation to alleviate exercise intolerance in HF; leaves open clinical translation.
The primary finding of this manuscript is that voltage-gated potassium (Kv) channel dysfunction in DRGs plays a critical role in mediating the exaggerated EPR and muscle afferent sensitization in chronic heart failure (CHF). We propose that manipulation of Kv channels in DRG neurons could be considered as a potential new approach to reduce the exaggerated sympathoexcitation and to improve exercise intolerance in CHF, which can ultimately facilitate an improved quality of life and reduce mortality.
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Hong et al. (2021) studied Chronic heart failure. Voltage-gated potassium (Kv) channel dysfunction was evaluated on Exaggerated exercise pressor reflex and muscle afferent sensitization. Voltage-gated potassium channel dysfunction in dorsal root ganglia mediates the exaggerated exercise pressor reflex and muscle afferent sensitization in rats with chronic heart failure.
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