Population
rats with chronic heart failure (CHF) and sham rats
Comparison
static contraction, passive stretch, hindlimb… vs sham rats
Design
Preclinical
Authors
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May contribute to exercise intolerance in heart failure; hypothesis-generating for P2X3/VR1 modulation, requires human validation.
In a rat model of chronic heart failure, group III muscle afferents are sensitized and group IV afferents are desensitized, which is associated with the dysfunction of P2X and VR1 receptors.
Wang et al. (2010) studied this question.
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