April 12, 2012AJP Regulatory Integrative and Comparative Physiology
Exercise training prevents skeletal muscle afferent sensitization in rats with chronic heart failure
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Key result
Exercise training prevented the sensitization of group III afferents and partially prevented the blunted sensitivity of group IV afferents in rats with chronic heart failure, partly by restoring P2X and TRPV1 receptor function.
Why the study?
Does exercise training prevent skeletal muscle afferent sensitization in rats with chronic heart failure?
Population
Rats with chronic heart failure (CHF) and sham-operated rats
Comparison
Exercise training (ExT) vs Sedentary (Sed) condition
Design
Preclinical
Authors
Discussion
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Implication
Should not yet alter ExT timing in CHF; leaves open whether afferent improvements translate to human exercise tolerance.
Structured PICO
Does exercise training prevent skeletal muscle afferent sensitization in rats with chronic heart failure?
P
Population
167 male Sprague-Dawley rats with chronic heart failure induced by coronary ligation or sham operation, subjected to exercise training or sedentary behavior.
I
Intervention
Exercise training (ExT)
C
Comparator
Sedentary (Sed) condition
O
Outcome
Discharge of mechanically sensitive (group III) and metabolically sensitive (group IV) afferents in response to static contraction, passive stretch, and hindlimb intra-arterial injection of capsaicinsurrogate
Main Result
Absolute Event Rate: 13.7% vs 23%
p-value: p=<0.05
Exercise training improves abnormal sensitization of muscle afferents in chronic heart failure rats by restoring P2X and TRPV1 receptor function.
Limitations
- PPADS antagonizes most P2X receptors but also antagonizes P2Y receptors
- The study did not exclude the possibility that a central mechanism is also involved in the beneficial effect of exercise training on the exaggerated exercise pressor reflex in the chronic heart failure state
Cite This Study
Wang et al. (2012) studied Chronic heart failure (n=167). Exercise training vs. Sedentary was evaluated on Firing duration of group III afferents during contraction (p=<0.05). Exercise training prevented the sensitization of group III afferents and partially prevented the blunted sensitivity of group IV afferents in rats with chronic heart failure, partly by restoring P2X and TRPV1 receptor function.
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