Key result
Exercise training improved baroreflex sensitivity in rabbits with chronic heart failure by reducing central angiotensin II and its receptors (P<0.01).
Why the study?
Does exercise training improve baroreflex sensitivity via an angiotensin II-dependent mechanism in rabbits with chronic heart failure?
Population
Rabbits with chronic heart failure (CHF) induced by ventricular pacing (360-380 beats/min) for 3 wk
Comparison
Exercise training for 4 wk at 15-18 m/min, 6… vs CHF and CHF-EX + ANG II infusion
Design
Preclinical
Follow-up
4 weeks
Authors
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May support sympathetic modulation by exercise in human CHF; leaves open confirmation in randomized trials.
Does exercise training improve baroreflex sensitivity via an angiotensin II-dependent mechanism in rabbits with chronic heart failure?
p-value: P < 0.01 for sodium nitroprusside and P < 0.001 for phenylephrine
Exercise training improves baroreflex function and reduces sympathetic nerve activity in chronic heart failure by downregulating angiotensin II and its receptors in the central nervous system.
Mousa et al. (2007) studied Chronic heart failure. Exercise training vs. No exercise or exercise with ANG II infusion was evaluated on Baroreflex sensitivity slopes (p=P < 0.01 for sodium nitroprusside and P < 0.001 for phenylephrine). Exercise training improved baroreflex sensitivity in rabbits with chronic heart failure by reducing central angiotensin II and its receptors (P<0.01).
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