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November 1, 2003Journal of Applied Physiology

Amelioration of depressed cardiopulmonary reflex control of sympathetic nerve activity by short-term exercise training in male rabbits with heart failure

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Why the study?

Does short-term exercise training improve cardiopulmonary reflex sensitivity in a rabbit model of pacing-induced heart failure?

Population

Male New Zealand White rabbits with chronic heart failure induced by chronic ventricular pacing, and normal…

Comparison

Short-term exercise training vs No exercise training

Design

Preclinical

Key result

Short-term exercise training in rabbits with chronic heart failure significantly improved cardiopulmonary reflex sensitivity from 0.0 to -5.0 %delta RSNA/mmHg (P<0.05).

Authors

RPRainer U. PliquettKCKurtis G. CornishKPKaushik P. Patel

Discussion

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Overview

Does not support clinical adoption in HF; hypothesis-generating for exercise effects on reflexes in animal models.

Structured PICO

Does short-term exercise training improve cardiopulmonary reflex sensitivity in a rabbit model of pacing-induced heart failure?

P
Population
Male New Zealand White rabbits with pacing-induced chronic heart failure or normal controls, subjected to short-term exercise training.
I
Intervention
Short-term exercise training
C
Comparator
No exercise training (sedentary CHF rabbits and normal controls)
O
Outcome
Cardiopulmonary (CP) reflex sensitivity (slope of the relationship between renal sympathetic nerve activity [RSNA] and left ventricular end-diastolic pressure [LVEDP] during volume expansion)surrogate

Main Result

Absolute Event Rate: -5% vs 0%

p-value: p=<0.05

Short-term exercise training partially restores depressed cardiopulmonary reflex sensitivity and lowers resting sympathetic nerve activity in a rabbit model of pacing-induced heart failure.

Cite This Study

Pliquett et al. (2003) studied Chronic heart failure. Short-term exercise training vs. No exercise training was evaluated on Cardiopulmonary reflex sensitivity (slope of RSNA vs LVEDP) (p=<0.05). Short-term exercise training in rabbits with chronic heart failure significantly improved cardiopulmonary reflex sensitivity from 0.0 to -5.0 %delta RSNA/mmHg (P<0.05).

synapsesocial.com/papers/6a92fa6aa5dd9c5ed4e9c741https://doi.org/10.1152/japplphysiol.00486.2003
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