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April 1, 1999Journal of Applied Physiology

Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure

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Population

Conscious rabbit model of pacing-induced chronic heart failure (3-4 weeks of pacing)

Comparison

Stimulation of peripheral chemoreceptors by… vs Sham rabbits

Design

Preclinical

Authors

SSShu-Yu SunWWW. WangIZIrving H. Zucker

Discussion

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Overview

Suggests chemoreflex hyperactivity drives sympathetic activation in experimental CHF; hypothesis-generating for human translation.

Structured PICO

P
Population
Conscious rabbit model of pacing-induced chronic heart failure (3-4 weeks of pacing)
I
Intervention
Stimulation of peripheral chemoreceptors by isocapnic/hypoxic gases and inhibition by inhalation of 100% O2
C
Comparator
Sham rabbits
O
Outcome
Renal sympathetic nerve activity (RSNA) and minute volume (MV) of ventilationsurrogate

In a rabbit model of pacing-induced heart failure, enhanced peripheral chemoreflex function contributes to sympathetic activation.

Cite This Study

Sun et al. (1999) studied this question.

synapsesocial.com/papers/6a6f80e7ce524a4339c36d46https://doi.org/10.1152/jappl.1999.86.4.1264
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