Key result
Exercise training in rats with heart failure normalized the augmented activation of the paraventricular nucleus and sympathetic outflow via an angiotensinergic mechanism.
Why the study?
Does exercise training normalize enhanced sympathetic activation from the paraventricular nucleus via angiotensinergic mechanisms in rats with chronic heart failure?
Population
Rats with heart failure induced by left coronary artery ligation, and sham-operated controls
Comparison
Exercise training vs Sedentary condition (no exercise training)
Design
Preclinical
Follow-up
3 weeks
Authors
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Does not change clinical practice; hypothesis-generating for exercise effects on central angiotensinergic sympathetic control in heart failure.
Does exercise training normalize enhanced sympathetic activation from the paraventricular nucleus via angiotensinergic mechanisms in rats with chronic heart failure?
Exercise training may alleviate elevated sympathetic outflow in heart failure by normalizing angiotensinergic mechanisms within the paraventricular nucleus.
Zheng et al. (2012) studied Heart failure. Exercise training (treadmill running) vs. Sedentary was evaluated on Sympathetic outflow and paraventricular nucleus activation (FosB-positive cells, RSNA, MAP, HR responses to ANG II). Exercise training in rats with heart failure normalized the augmented activation of the paraventricular nucleus and sympathetic outflow via an angiotensinergic mechanism.
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