Key result
Chymase and total angiotensin II-forming activities, but not ACE activity, were significantly higher in chronic cirrhosis patients and correlated with the degree of liver fibrosis.
Observational (n=77)
Chymase-dependent angiotensin II formation is significantly elevated in chronic liver cirrhosis and correlates with the degree of fibrosis, suggesting a role in disease progression.
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Chymase-dependent Ang II formation associates with fibrosis severity in cirrhosis; hypothesis-generating for targeted inhibition pending prospective trials.
Komeda et al. (2007) conducted an observational in Liver fibrosis and cirrhosis (n=77). Chymase and total angiotensin II-forming activities, but not ACE activity, were significantly higher in chronic cirrhosis patients and correlated with the degree of liver fibrosis.
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