Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 2, 2007Clinical Science

Liver fibrosis: a balance of ACEs?

View Full Paper
Ask AI
Bookmark
Share

Why the study?

What is the role of the renin-angiotensin system, angiotensin II, and ACE2 in chronic liver injury and fibrogenesis?

Population

Humans with chronic liver disease and experimental animal models of chronic liver injury

Design

Review

Authors

FWFiona J. WarnerJLJohn LubelGMGeoffrey W. McCaughan

Discussion

Loading...

Member takes

Overview

May inform RAS-targeted antifibrotic strategies in liver disease; leaves open clinical translation pending human trials.

Structured PICO

What is the role of the renin-angiotensin system, angiotensin II, and ACE2 in chronic liver injury and fibrogenesis?

P
Population
Humans with chronic liver disease and experimental animal models of chronic liver injury
I
Intervention
Modulation of the renin-angiotensin system (RAS), including ACE inhibitors, angiotensin type 1 receptor antagonists, and the ACE2-angiotensin-(1-7)-Mas axis
O
Outcome
Liver fibrosis and tissue injury

The renin-angiotensin system plays a significant role in liver fibrogenesis, and its modulation, particularly through the ACE2-angiotensin-(1-7)-Mas axis, represents a potential therapeutic target for chronic liver disease.

Cite This Study

Warner et al. (2007) studied this question.

synapsesocial.com/papers/6a82ad4ffecb6623ab8d5b1fhttps://doi.org/10.1042/cs20070026
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1–7)2006 · 335 citations
  2. 2Upregulation of Angiotensin-Converting Enzyme 2 After Myocardial Infarction by Blockade of Angiotensin II Receptors2004 · 572 citations
  3. 3Active fragments of angiotensin II: enzymatic pathways of synthesis and biological effects1997 · 94 citations
  4. 4A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-92000 · 3,176 citations
  5. 5Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase2002 · 1,432 citations