What does this research mean for the field?

Angiotensin II regulates plasminogen activation in the vasculature by inducing the expression of plasminogen activator inhibitor-1 (PAI-1) and PAI-2 in vascular endothelial and smooth muscle cells via AT1 receptor-mediated pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1995Journal of Clinical InvestigationOpen Access

Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells.

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Why the study?

Does Angiotensin II induce plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells?

Population

Rat microvessel endothelial (RME) cells and rat aortic smooth muscle cells (RASMC)

Comparison

Angiotensin II (AII) and Arg8-vasopressin (AVP) vs Untreated cells and cells treated with specific…

Design

Preclinical

Authors

EFEdward P. FeenerKalVista Pharmaceuticals (United States)JNJ M NorthrupBrigham and Women's Hospital LALloyd Paul AielloJoslin Diabetes Center

Discussion

Member takes

Implication

Ang II may impair vascular fibrinolysis via PAI induction; leaves open relevance to human disease progression.

Structured PICO

Does Angiotensin II induce plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells?

Population

Rat microvessel endothelial (RME) cells and rat aortic smooth muscle cells (RASMC)

Intervention

Angiotensin II (AII) and Arg8-vasopressin (AVP)

Comparator

Untreated cells and cells treated with specific receptor antagonists (DuP 735, PD123319) or kinase inhibitors

Outcome

Expression of plasminogen activator inhibitor (PAI)-1 and PAI-2 mRNA and proteinsurrogate

Angiotensin II induces PAI-1 and PAI-2 expression in vascular endothelial and smooth muscle cells, suggesting a mechanism by which it regulates vascular plasminogen activation.

Cite This Study

Feener et al. (1995) studied this question.

synapsesocial.com/papers/6a1db85b984ea5c2d0ce322f https://doi.org/10.1172/jci117786

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Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider