Why the study?
Does AT1 receptor antagonism with candesartan reduce Ang II-induced PAI-1 gene expression in rat vascular and cardiac tissues?
Population
Rat aortic smooth muscle cells, neonatal rat cardiomyocytes, Sprague-Dawley rats, spontaneously hypertensive…
Comparison
Angiotensin peptides and AT1 receptor antagonist… vs Vehicle/control conditions, or normotensive…
Design
Preclinical
Follow-up
Up to 1 week
Authors
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Hypothesis-generating for AT1-mediated PAI-1 reduction in hypertension; human studies needed before clinical translation.
Does AT1 receptor antagonism with candesartan reduce Ang II-induced PAI-1 gene expression in rat vascular and cardiac tissues?
The AT1 receptor mediates the stimulatory effects of Ang II on aortic and cardiac PAI-1 gene expression, which can be significantly attenuated by the AT1 antagonist candesartan.
Bouchie et al. (2000) studied this question.
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