Sildenafil Improves Exercise Hemodynamics and Oxygen Uptake in Patients With Systolic Heart Failure
Key result
A single 50 mg oral dose of sildenafil improved peak VO2 by 15+/-9% and reduced VE/VCO2 slope by 16+/-5% in patients with systolic heart failure and secondary pulmonary hypertension.
Why the study?
Does a single oral dose of sildenafil 50 mg improve exercise capacity and hemodynamics in patients with chronic systolic heart failure?
Population
13 patients with chronic systolic heart failure, New York Heart Association (NYHA) class III.
Comparison
Single oral dose of sildenafil 50 mg. vs Baseline measurements before sildenafil…
Design
Cohort
Follow-up
60 minutes
Authors
Discussion
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Member takes
Implication
Suggests potential acute hemodynamic benefit in systolic HF with secondary pulmonary hypertension; leaves open whether chronic s.
Structured PICO
Does a single oral dose of sildenafil 50 mg improve exercise capacity and hemodynamics in patients with chronic systolic heart failure?
P
Population
13 patients with chronic systolic heart failure, New York Heart Association (NYHA) class III.
I
Intervention
Single oral dose of sildenafil 50 mg.
C
Comparator
Baseline measurements before sildenafil administration.
O
Outcome
Right heart hemodynamics, gas exchange (including peak VO2 and VE/VCO2 slope), and first-pass radionuclide ventriculography at rest and with cycle ergometry 60 minutes after administration.surrogate
Main Result
p-value: p=<0.05
A single 50 mg dose of sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure, specifically those with secondary pulmonary hypertension.
Cite This Study
Lewis et al. (2006) studied Systolic Heart Failure (n=13). Sildenafil vs. Baseline (before administration) was evaluated on Exercise capacity (Peak VO2) and exercise hemodynamics (p=<0.05). A single 50 mg oral dose of sildenafil improved peak VO2 by 15+/-9% and reduced VE/VCO2 slope by 16+/-5% in patients with systolic heart failure and secondary pulmonary hypertension.