Key result
Sildenafil did not significantly decrease mean blood pressure compared to placebo in patients with left systolic heart failure (mean difference 1.16 mm Hg; 95% CI -1.6 to 5.1; P>.05).
Why the study?
Does sildenafil improve mean blood pressure in patients with left systolic heart failure?
RCT (n=106)
Double-blind
1:1
No
Does sildenafil improve mean blood pressure in patients with left systolic heart failure?
Mean Difference: 1.16 (95% CI -1.6–5.1)
p-value: p=>.05
Sildenafil is well tolerated and does not significantly decrease mean blood pressure or improve exercise capacity in patients with left systolic heart failure.
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Sildenafil does not reduce mean blood pressure in left systolic heart failure; confirms neutral hemodynamic effect in this population.
Amin et al. (2012) conducted an RCT in Left systolic heart failure (n=106). Sildenafil vs. Placebo was evaluated on Mean blood pressure (MD 1.16 mm Hg, 95% CI -1.6 to 5.1, p=>.05). Sildenafil did not significantly decrease mean blood pressure compared to placebo in patients with left systolic heart failure (mean difference 1.16 mm Hg; 95% CI -1.6 to 5.1; P>.05).
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