Why the study?
Does tocainide have proarrhythmic effects in patients with dilated cardiomyopathy?
Does tocainide have proarrhythmic effects in patients with dilated cardiomyopathy?
Tocainide may have proarrhythmic effects in patients with dilated cardiomyopathy, as demonstrated by the induction of sustained monomorphic ventricular tachycardia during electrophysiological testing.
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May signal proarrhythmic risk with tocainide in dilated cardiomyopathy; single case leaves open need for confirmatory data.
A patient with a dilated cardiomyopathy experienced a cardiac arrest when taking tocainide for asymptomatic nonsustained ventricular tachycardia. After successful resuscitation from ventricular fibrillation and exclusion of a myocardial infarction, an electrophysiological evaluation was performed. Drug-free study #1 revealed no induction of ventricular tachycardia. A tocainide study revealed induction of sustained monomorphic ventricular tachycardia. Drug-free study #2 revealed induction of nonsustained ventricular tachycardia. This report illustrates a possible proarrhythmic effect of tocainide.
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Brownstein et al. (1988) studied this question.
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