May 1, 1978CirculationOpen Access

Long-term tocainide therapy for ventricular arrhythmias.

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Why the study?

Does tocainide control ventricular arrhythmias in patients refractory to quinidine, procainamide, or propranolol?

Population

17 patients with ventricular arrhythmias whose arrhythmias could not be managed with quinidine, procainamide…

Design

Case_series

Follow-up

Long-term

Authors

RWRoger A. WinkleElectrophysiology PMP J MeffinFlinders University DHDonald C. HarrisonElectrophysiology

Discussion

Member takes

Implication

May support tocainide in refractory ventricular arrhythmias; leaves open efficacy and safety pending randomized trials.

Structured PICO

Does tocainide control ventricular arrhythmias in patients refractory to quinidine, procainamide, or propranolol?

Population

17 patients with ventricular arrhythmias (recurrent and sustained ventricular tachycardia and/or fibrillation in 9, symptomatic but unsustained in 3, frequent but only mildly symptomatic ventricular irritability in 5) whose arrhythmias could not be managed with quinidine, procainamide or propranolol.

Intervention

Tocainide 300 to 700 mg every 8 hours

Outcome

Control of arrhythmias (defined as continued reduction of ectopic beats and/or control of symptomatic recurrences)composite

Tocainide provides effective long-term control of ventricular arrhythmias in approximately half of patients who are refractory to conventional antiarrhythmic therapies.

Cite This Study

Winkle et al. (1978) studied this question.

synapsesocial.com/papers/6a722a7831a3df824329fc10 https://doi.org/10.1161/01.cir.57.5.1008

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Long-term tocainide therapy for ventricular arrhythmias.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Long-term tocainide therapy for ventricular arrhythmias.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider