Chronic tocainide therapy for refractory high‐grade ventricular arrhythmias
Why the study?
Does tocainide control refractory symptomatic ventricular arrhythmias in patients with complex ventricular ectopic activity?
Population
21 patients with symptomatic complex ventricular ectopic activity refractory to currently available…
Design
Case_series
Follow-up
3 days to 35 months (mean 13.6 months)
Authors
Discussion
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Member takes
Implication
May support use in refractory cases; leaves open randomized confirmation of efficacy and safety.
Structured PICO
Does tocainide control refractory symptomatic ventricular arrhythmias in patients with complex ventricular ectopic activity?
P
Population
21 patients with symptomatic complex ventricular ectopic activity (10 with hemodynamically significant ventricular tachycardia) refractory to currently available antiarrhythmics
I
Intervention
Tocainide (oral analog of lidocaine) administered for periods of 3 days to 35 months (mean 13.6 months)
O
Outcome
Control of refractory symptomatic ventricular arrhythmias
Tocainide is an effective and safe oral antiarrhythmic agent for patients with refractory complex ventricular ectopic activity, with lidocaine responsiveness predicting its efficacy.
Cite This Study
Haffajee et al. (1983) studied this question.