Tocainide can cause severe, multi-system adverse reactions requiring hospitalization, highlighting the need for caution when prescribing this antiarrhythmic agent.
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Tocainide may cause severe multi-system toxicity; case reports leave open the incidence and mechanisms of such reactions.
Tocainide is a primary analog of lidocaine with antiarrhythmic properties used to treat ventricular rhythm disorders. A 76-year-old man with benign paroxysmal premature ventricular contractions was treated with tocainide and developed a generalized maculopapular lupoid eruption, bleeding from the lips and gingivae, vertigo, gross tremors of the extremities, fever, and short-term memory loss, which required hospitalization. The patient recovered slowly over three months with no permanent sequelae after discontinuing the drug and receiving rigorous supportive care. His excellent physical status and absence of concomitant illness contributed to an uneventful recovery. Tocainide is a potent cardioactive drug with a long biological half-life and should be used with caution.
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Dunn et al. (1988) studied this question.
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