What does this research mean for the field?

Measuring EBV p18-VCA antibodies in dried whole blood spots is a valid, sensitive, and reliable minimally invasive method for assessing cell-mediated immunity, which reveals that stressful life events are positively associated with elevated antibody levels in adolescent girls. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 2000Psychosomatic Medicine

Epstein-Barr Virus Antibodies in Whole Blood Spots: A Minimally Invasive Method for Assessing an Aspect of Cell-Mediated Immunity

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Population

Subsample of 9, 11, and 13 year-old children participating in the Great Smoky Mountains Study in North…

Comparison

Measurement of EBV p18-VCA antibodies in whole… vs Plasma and indirect immunofluorescence methods

Design

Cohort

Authors

TMThomas W. McDadeNorthwestern University JSJoy F. StallingsEmory University AAAdrian AngoldNorthwestern University

Discussion

Member takes

Implication

Supports dried blood spot use for scalable EBV immunity assessment in community studies; leaves open sex-specific life event associations.

Structured PICO

Population

Subsample of 9, 11, and 13 year-old children participating in the Great Smoky Mountains Study in North Carolina, stratified by age, sex, and degree of overall life strain.

Intervention

Measurement of EBV p18-VCA antibodies in whole blood spots

Comparator

Plasma and indirect immunofluorescence methods

Outcome

Precision, reliability, stability, and validity of the blood spot method, and association of life events with p18-VCA antibody levelssurrogate

Whole blood spots provide a valid, minimally invasive method for measuring EBV p18-VCA antibodies to assess cell-mediated immunity in large community-based studies.

Cite This Study

McDade et al. (2000) studied this question.

synapsesocial.com/papers/6a1dbab7984ea5c2d0ce3602 https://doi.org/10.1097/00006842-200007000-00015

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Implication

Supports dried blood spot use for scalable EBV immunity assessment in community studies; leaves open sex-specific life event associations.

Epstein-Barr Virus Antibodies in Whole Blood Spots: A Minimally Invasive Method for Assessing an Aspect of Cell-Mediated Immunity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Epstein-Barr Virus Antibodies in Whole Blood Spots: A Minimally Invasive Method for Assessing an Aspect of Cell-Mediated Immunity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider