What does this research mean for the field?

The large subunit of the NADPH oxidase cytochrome b (gp91-phox) functions as the arachidonate-activable H+ channel in human neutrophils. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1995Journal of Biological ChemistryOpen Access

The Arachidonate-activable, NADPH Oxidase-associated H+ Channel

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Population

Differentiated HL60 cells, EBV transformed B lymphocyte cell lines from normal and CGD patients, CHO cells…

Comparison

Transfection with gp91-phox cDNA or induction of… vs Cells lacking specific phox proteins or…

Design

Preclinical

Authors

LHL. M. HendersonLeicester Royal Infirmary GBGeorge BantingUniversity of Bristol JCJoseph ChappellUniversity of Kentucky

Discussion

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Implication

Extends mechanistic insight into neutrophil superoxide generation; leaves open clinical implications for inflammatory disorders.

Structured PICO

Population

Differentiated HL60 cells, EBV transformed B lymphocyte cell lines from normal and CGD patients, CHO cells, and undifferentiated HL60 cells

Intervention

Transfection with gp91-phox cDNA or induction of differentiation with succinyl acetone

Comparator

Cells lacking specific phox proteins (p47-phox, p67-phox, gp91-phox) or undifferentiated cells

Outcome

Expression of H+ channel activity and generation of superoxidesurrogate

This basic science study identifies gp91-phox as the arachidonate-activable H+ channel in human neutrophils.

Cite This Study

Henderson et al. (1995) studied this question.

synapsesocial.com/papers/6a1dc55bd10dad54e1ef5188 https://doi.org/10.1074/jbc.270.11.5909

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The Arachidonate-activable, NADPH Oxidase-associated H+ Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Arachidonate-activable, NADPH Oxidase-associated H+ Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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