Key result
A voltage-gated highly H(+)-selective conductance was present in both normal and cytochrome b-deficient monocytes, indicating the transporter exists independently of cytochrome b.
Population
Neutrophils and purified blood monocytes from normal donors and cytochrome b-deficient chronic granulomatous…
Comparison
Manipulation of cytosolic pH and transmembrane… vs Normal cells versus cytochrome b-deficient CGD…
Design
Preclinical
Authors
Loading...
Challenges view of cytochrome b forming the H+ channel; hypothesis-generating for NADPH oxidase regulation in leukocytes, not yet for clinical use.
The H+ conductive pathway is present in leukocytes devoid of cytochrome b, implying that the NADPH oxidase regulates rather than forms the H+ channel.
Nanda et al. (1994) studied Chronic granulomatous disease. Cytochrome b deficiency vs. Normal cells was evaluated on Presence of H+ conductive pathway. A voltage-gated highly H(+)-selective conductance was present in both normal and cytochrome b-deficient monocytes, indicating the transporter exists independently of cytochrome b.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: