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March 29, 2021Scientific ReportsOpen Access

In women with polycystic ovary syndrome, a baseline diagnosis of metabolic syndrome significantly increased the risk of subsequent non-alcoholic fatty liver disease occurrence (HR 5.6).

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Why the study?

The study was conducted to evaluate risk factors leading to non-alcoholic fatty liver disease occurrence in women with polycystic ovary syndrome.

Population

586 women diagnosed with PCOS aged 13–35 years

Comparison

PCOS women with NAFLD vs those without

Design

Retrospective cohort study

Key result

In women with polycystic ovary syndrome, a baseline diagnosis of metabolic syndrome significantly increased the risk of subsequent non-alcoholic fatty liver disease occurrence (HR 5.6).

Authors

YWYoung Bin WonSSSeok Kyo SeoBYBo Hyon Yun

Discussion

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Member takes

Overview

May warrant NAFLD surveillance in PCOS with MetS; extends associations but requires prospective validation.

Study Design

Type

Cohort (n=586)

Multicenter

No

Structured PICO

P
Population
586 women diagnosed with polycystic ovary syndrome (PCOS) aged 13–35 years at a university hospital gynecology department.
O
Outcome
Occurrence of non-alcoholic fatty liver disease (NAFLD)

Main Result

Effect estimate: HR 5.6 (95% CI 2.2-14.4)

p-value: p=<0.01

In women with PCOS, the presence of metabolic syndrome and hyperandrogenism are significant risk factors for the subsequent development of non-alcoholic fatty liver disease.

Limitations

  • Retrospective design
  • Missing data for some variables may have diluted potential relationships
  • Selective bias in the diagnostic flow of NAFLD as liver evaluation was mostly done if liver enzymes were abnormal
  • Mild expressions of NAFLD without liver enzyme abnormality were not included
  • Waist circumference was not checked in most patients, so central obesity was not properly established
  • Not all patients had values available for all data items
  • Significantly higher number of adults compared to adolescents
  • Selective bias in the diagnostic flow of NAFLD (mild expressions without liver enzyme abnormality not included)
  • Waist circumference was not checked in most patients

Cite This Study

Won et al. (2021) conducted a cohort in Polycystic ovary syndrome (PCOS) (n=586). Metabolic syndrome (MetS) vs. No metabolic syndrome was evaluated on Subsequent NAFLD occurrence (HR 5.6, 95% CI 2.2-14.4, p=<0.01). In women with polycystic ovary syndrome, a baseline diagnosis of metabolic syndrome significantly increased the risk of subsequent non-alcoholic fatty liver disease occurrence (HR 5.6).

synapsesocial.com/papers/6a1dcefc79ea62caf6602494https://doi.org/10.1038/s41598-021-86697-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Systematic Review of the Risk of Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome2022 · 10 citations
  2. 2Hepatic steatosis in women with polycystic ovary syndrome2023 · 17 citations
  3. 3Risk factors of Non Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome2025
  4. 4Hepatic Steatosis Index as an Indicator of Non-alcoholic Fatty Liver Disease among Young Women With Polycystic Ovarian Syndrome2022 · 1 citations
  5. 5Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome2014 · 101 citations