Key result
Women of reproductive age with polycystic ovary syndrome have a significantly increased risk of developing non-alcoholic fatty liver disease, with hyperandrogenism acting as the most influential risk factor.
Why the study?
Is polycystic ovary syndrome associated with an increased risk of non-alcoholic fatty liver disease in women?
Population
Women with polycystic ovary syndrome (PCOS) (11 observational studies)
Comparison
Polycystic ovary syndrome (PCOS) vs Healthy controls
Design
Systematic_review
Authors
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Supports NAFLD screening in reproductive-age women with PCOS; confirms hyperandrogenism as dominant driver and extends meta-analytic evidence.
Systematic Review
Is polycystic ovary syndrome associated with an increased risk of non-alcoholic fatty liver disease in women?
Women with PCOS have an increased risk of developing NAFLD, particularly hepatic steatosis, driven primarily by hyperandrogenism, highlighting the need for screening in this population.
Shahbaz et al. (2022) conducted a systematic review in Polycystic Ovary Syndrome (PCOS). Polycystic Ovary Syndrome (PCOS) vs. Women without PCOS / healthy controls was evaluated on Risk or prevalence of non-alcoholic fatty liver disease (NAFLD). Women of reproductive age with polycystic ovary syndrome have a significantly increased risk of developing non-alcoholic fatty liver disease, with hyperandrogenism acting as the most influential risk factor.
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