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March 1, 1986The Journal of Clinical Pharmacology

Clinical Experience With Esmolol, A Short‐Acting Beta‐Adrenergic Blocker In Cardiac Arrhythmias and Myocardial Ischemia

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Why the study?

Does intravenous esmolol effectively and safely control heart rate in patients with supraventricular tachyarrhythmias and acute myocardial ischemia?

Population

377 patients, comprising 358 patients with supraventricular tachyarrhythmias and 19 patients with myocardial…

Comparison

Esmolol infused intravenously in doses ranging… vs Placebo, propranolol, or baseline.

Design

Review, Included open-label studies; blinding for controlled studies not…

Follow-up

Up to 24 hours of infusion

Authors

RSRuey J. SungStanford UniversityLBLori BlanskiTulane UniversityJKJames M. KirshenbaumBrigham and Women's Hospital

Discussion

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Implication

May support titratable esmolol use in unstable SVT; leaves open prospective RCTs in acute ischemia.

Structured PICO

Does intravenous esmolol effectively and safely control heart rate in patients with supraventricular tachyarrhythmias and acute myocardial ischemia?

P
Population
377 patients, comprising 358 patients with supraventricular tachyarrhythmias (SVTs) and 19 patients with myocardial ischemia (acute myocardial infarction or unstable angina).
I
Intervention
Esmolol infused intravenously in doses ranging from 25 to 300 micrograms/kg/min for durations up to 24 hours.
C
Comparator
Placebo, propranolol, or baseline (depending on the specific study).
O
Outcome
Heart rate control (defined as a reduction of at least 15% to 20% from average baseline heart rate, heart rate less than 100 beats/min, or conversion to normal sinus rhythm).surrogate

Esmolol is an effective, ultra-short-acting beta-blocker for rapid heart rate control in patients with SVT and myocardial ischemia, offering a rapid offset of action that is beneficial in critically ill patients.

Cite This Study

Sung et al. (1986) studied this question.

synapsesocial.com/papers/6a1dcff3871ff5209bef66eahttps://doi.org/10.1002/j.1552-4604.1986.tb02983.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Esmolol: A new ultrashort-acting beta-adrenergic blocking agent for rapid control of heart rate in postoperative supraventricular tachyarrhythmias1985 · 82 citations
  2. 2A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction1982 · 1,380 citations
  3. 3Timolol-Induced Reduction in Mortality and Reinfarction in Patients Surviving Acute Myocardial Infarction1981 · 1,677 citations
  4. 4Pharmacology of ASL-8052, a Novel β-Adrenergic Receptor Antagonist with an Ultrashort Duration of Action1983 · 82 citations
  5. 5Reduction by Propranolol of Myocardial Necrosis following Temporary Coronary Artery Occlusion in Dogs1973 · 227 citations