Why the study?
Is esmolol effective and titratable compared to propranolol for treating supraventricular arrhythmias and perioperative tachycardia/hypertension?
Is esmolol effective and titratable compared to propranolol for treating supraventricular arrhythmias and perioperative tachycardia/hypertension?
Esmolol provides an effective, rapidly reversible, and titratable intravenous beta-blocker option for acute management of supraventricular arrhythmias and perioperative adrenergic stimulation.
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May support esmolol for acute SVT or perioperative use needing rapid reversal; leaves open prospective randomized confirmation versus propranolol.
Esmolol is an ultrashort-acting, cardioselective, intravenous beta-blocker with an elimination half-life of about nine minutes. After administration of a loading dose, its full therapeutic effect is evident within five minutes. Its efficacy in treating supraventricular arrhythmias is equal to that of propranolol, but unlike propranolol, the action of esmolol is titratable and is largely reversed within 10 to 30 minutes after stopping its administration. Esmolol is also effective in attenuating life-threatening perioperative tachycardia and hypertension caused by adrenergic stimulation in high-risk patients.
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Joel O. Covinsky (1987) studied this question.
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