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May 6, 1988Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Controlled Beta‐Receptor Blockade with Esmolol and Flestolol

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Key result

Esmolol, an ultrashort-acting cardioselective beta-blocker with a nine-minute half-life, allows rapid titration and reversal of pharmacological effects in critically ill patients.

Population

Critically ill patients with cardiovascular diseases, including supraventricular tachycardia

Design

Review

Authors

VMVishnu MurthyUniversity of California, Los AngelesWFWilliam H. FrishmanGeneral Cardiology

Discussion

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Implication

May enable precise beta-blockade in unstable patients; hypothesis-generating pending randomized outcome data.

Structured PICO

P
Population
Critically ill patients with cardiovascular diseases, including supraventricular tachycardia
I
Intervention
Esmolol and flestolol (ultrashort-acting beta-receptor-blocking agents)

The ultrashort duration of action of esmolol and flestolol allows for precise titration and rapid reversal of beta-blockade, expanding their utility in critically ill patients.

Cite This Study

Murthy et al. (1988) conducted a review in Supraventricular tachycardia and cardiovascular diseases. Esmolol and Flestolol was evaluated. Esmolol, an ultrashort-acting cardioselective beta-blocker with a nine-minute half-life, allows rapid titration and reversal of pharmacological effects in critically ill patients.

synapsesocial.com/papers/6a61fb05f5a6cede3a89b9cchttps://doi.org/10.1002/j.1875-9114.1988.tb04071.x
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