Key result
Alcoholism is linked to an over 3-fold higher risk of medication-related problems in hypertension.
Why the study?
Medication-related problems in hypertensive patients are common and associated with high mortality, complications, prolonged hospital stays, and increased healthcare costs.
What is the prevalence and what are the predictors of medication-related problems in patients with hypertension?
Observational (n=384)
No
What is the prevalence and what are the predictors of medication-related problems in patients with hypertension?
Odds Ratio: 3.25 (95% CI 1.46–7.23)
p-value: p=0.004
Medication-related problems are highly prevalent among hypertensive patients in Ethiopia, strongly predicted by alcoholism, advanced hypertension stage, comorbidities, and polypharmacy, highlighting the need for clinical pharmacist integration.
MRPs affect most hypertensives and associate with alcoholism; leaves open whether targeted interventions improve outcomes.
Background: Hypertension affects more than 1.4 billion people worldwide currently, with that number anticipated to climb to 1.6 billion by 2025 with high mortality and morbidity effects. Medication related problems in cardiovascular disease patients, especially among hypertension patients were found to be high and a critical problem which is associated with high mortality, complication, prolonged hospital stay, compromised quality of life and increase health care cost. Objective: To determine medication related problems and its predictors among hypertension patients on chronic follow-up at Jimma Medical Center. Methods: A prospective interventional study was conducted among hypertension patients from November 28, 2021 to June 30, 2022 at Jimma Medical Center. Medication related problems were classified and identified based on Pharmaceutical care network Europe drug classification tool version 9.0. Interventions were done through discussion with individual prescriber and patients. Consecutive sampling technique was used. Binary Logistic regression was used to identify independent predictors of medication related problems. Variables having P-values < 0.05 were considered statistically significant. Results: Among 384 hypertension patients included in the study, 219 (57.1%) were male. The mean (SD) age was 49.06+17.79. Two thirds of study participants had at least one medication related problem. A total of 483 MRPs were identified among 231 (60.15%) patients. Treatment effectiveness related problem (55.48%) was the most common observed medication related problems. Alcoholism (AOR; 3.15, 95% CI [1.46-7.23]), stage II hypertension (AOR=2.77, 95% CI= [3.53-4.66]); comorbidity (AOR=2.88, 95% CI= [1.47-5.66]) and polypharmacy (AOR=3.07, 95% CI= [1.57-5.99]) were the independent predictors of medication related problems. Conclusion: The prevalence of medication related problems was high among hypertensive patients. Alcoholism, stage II hypertension, comorbidity and poly-pharmacy were the predictors of medication related problems. Therefore, to overcome the problems, clinical pharmacists, physicians and other health care professionals have to work in collaboration.
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Garedow et al. (2023) conducted an observational in Hypertension (n=384). Alcoholism vs. Non-alcoholism was evaluated on Medication related problems (MRPs) (AOR 3.25, 95% CI 1.46-7.23, p=0.004). Alcoholism significantly increased the risk of medication-related problems among hypertensive patients (AOR 3.25), which were highly prevalent (60.15%) in this cohort.
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